AGT and acute respiratory distress syndrome: This accumulation results in an inflammatory response, leading to acute lung injury, ARDS, myocardial injury, and some times gastrointestinal manifestations of nausea and vomiting because of the systematic distribution of ACE2 in multiple organs.40 The serum angiotensin II level in patients with COVID-19 pneumonia is significantly higher than in healthy individuals and is linearly correlated with viral load.41 The ACE2 gene lies on the X-chromosome, Xp22.2.