Next, compared to non-WGD samples, the relatively frequent alterations of cancer genes were found in WGD samples, where genes MYC, EIF4EBP1, and FGFR1 displayed amplifications; DUSP4, LEPROTL1, NRG1, and WRN deletions; and MUC16 demonstrated mutations (P < 0.05, odds ratio >1; logistic regression). The gene discussed is WRN; the disease is cancer.