As reported before, the two concentrations (0.04 μg/mL and 0.4 μg/mL) of SN38 used were not cytotoxic on the fibroblasts and led to a global downregulation of genes involved in fibrosis in SSc patients (supplementary data Fig. 1), except for TIMP1 and CCL2 genes (supplementary data Fig. 2). The gene discussed is TIMP1; the disease is systemic sclerosis.