The aim of this retrospective study was to (1) assess the relationship between CK7 expression and cancer-specific survival of patients with CRC, and (2) elucidate correlations with well-established prognostic factors, such as tumor stage, tumor grade, histomorphology, CRC anatomical site, and mismatch-repair (MMR) status as widespread routinely used prognostic parameters in colorectal oncology. The gene discussed is KRT7; the disease is cancer.