VIM and hepatocellular carcinoma: According to the study by Ren et al., in hepatocellular carcinoma (HCC), CXCL10 has been reported to accelerate EMT of HCC cells; the epithelial marker (E-cadherin) was up-regulated while mesenchymal cell markers (N-cadherin, fibronectin and vimentin) were downregulated when CXCL10 was silenced; they witnessed exact opposite results of over-expression of CXCL1022.