ATXN1 and cerebellar ataxia: Noteworthy, due to the binding of our small molecules to an aggregated form of a simple polyQ-tract (e.g. Q46), it was not unexpected that CHDI-180 also bound to aggregated ataxin 1 (see Supplementary Fig. S11), another polyQ- repeat protein that plays a significant pathophysiological role in Spinocerebellar ataxia (reviewed in72–74).