However, the ARG signals were much lower in brain sections of 2 Sca mouse models75,76 when compared to the R6/2 HD model; the reason for the observed ARG signal differences between the Sca and HD models is not known, but may be attributed to differences in ataxin- vs. huntingtin-aggregate affinities and/or in mouse model aggregate load expression. Here, HTT is linked to Huntington disease.