However, binding of [3H]CHDI-626 in AD post-mortem brain tissues was significantly reduced compared to [3H]CHDI-180 (0.8 ± 0.6 fmol/mg for CHDI-626 vs. 5.6 ± 0.7 for CHDI-180), and close to CTRL levels, corroborating the results of the ADbh RBA. Here, CTRL is linked to Alzheimer disease.