For CHDI-180, we showed significantly greater binding in human HD cortical than in control cortical brain tissue (Fig. 6A), However, there was even greater signal/binding in AD tissue (to either HD or CTRL signal/binding), suggesting that this compound may have some affinity for AD pathology (e.g. beta amyloid plaques and/or tangles). The gene discussed is CTRL; the disease is Alzheimer disease.