AZD1480 inhibits STAT activity resulting in downregulation of SOCS-3 (a STAT3 target gene), and hyperphosphorylation of Src homology 2 domain-containing protein phosphatase 2 (SHP-2), which resulted in increased p44/42 MAPK phosphorylation in Hodgkin lymphoma cell lines35. Here, PTPN11 is linked to Hodgkins lymphoma.