Examination of these cohorts revealed that each of the downregulated miR-642a-5p target genes (WT1, NUAK1, RASSF3, and SKP2) is a potential driver of tumor progression, as each of their expression levels was higher in prostate tumor samples when compared to normal prostate tissue (Fig. 3c i–iv). This evidence concerns the gene RASSF3 and neoplasm.