Additionally, treatment of 22Rv1 and LNCaP PCa cells with a combination of both WT1 siRNA and a clinically available inhibitor of WT1 (Tanespimycin (17-AAG [17-(allylamino)-17-demethoxygeldanamycin]), resulted in a further reduction of cell growth than with WT1 siRNA or 17-AAG alone (Fig. 5f). This evidence concerns the gene WT1 and posterior cortical atrophy.