Such experiments would also allow to investigate a potential impact of Hmcn1 or Hmcn2 deficiency on the network formation of short fibulins in tissues, which, when disrupted, were shown to result in deficient elastic fiber formation with severe connective tissue consequences such as syndactyly, contractures, cutis laxa, aortic aneurysm formation and dissection18,23–25. This evidence concerns the gene HMCN1 and aortic aneurysm.