At 4 weeks of age, intravenous administration of AAV8-TBG-hGalns vectors at a dose similar to one of AAV9-CAG-Galns vectors used to treat MPSIVA rats, failed to provide complete restoration of chondrocyte size in the growth plate and articular cartilage of both MPSIVA mouse models during the 12-weeks monitoring period25. Here, GALNS is linked to mucopolysaccharidosis type 4A.