The cytotoxic T-cell subset showed an even more marked association with good prognosis: cases with low DNA-PKcs that had high levels of CD8 + iTILs were associated with a significantly better BCSS (HR 0.26, 95% CI 0.13–0.55; p < 0.001) (Fig. 4b), defining a group of patients with disease-specific survival better than 80% even 15 years after being diagnosed with triple-negative breast cancer. This evidence concerns the gene PRKDC and triple-negative breast carcinoma.