Given these findings, we explored whether expression of genes encoding the other components of the EFR3A signaling complex was increased in pancreatic adenocarcinoma, finding elevated mRNA levels for EFR3B (Supplementary Fig. 3b), PI4KA (Supplementary Fig. 3c), FAM126A (Supplementary Fig. 3d), and TTC7A (Supplementary Fig. 3e). Here, EFR3A is linked to pancreatic adenocarcinoma.