One such member of the Class-C JDP family, DnaJC7 (TPR2; tetratricopeptide repeat 2 protein), is highly expressed in the brain16 and loss of DnaJC7 function is implicated in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases17. The gene discussed is DNAJC7; the disease is amyotrophic lateral sclerosis.