Moreover, although a specific PTV (c.4582-2delAG > -) in SETD1A has been observed multiple times in people with schizophrenia and developmental disroders10, little is known generally about pleiotropic effects from individual rare coding variants in schizophrenia and NDDs (i.e., allelic pleiotropy). The gene discussed is SETD1A; the disease is schizophrenia.