Given the substantial enrichment over expectation of NDD variants in our primary variant set-based analysis (~7.5 fold), our analysis of allelic pleiotropy implicates variants in KMT2D, NF1, AUTS2, GRIA3, RUNX3, SLC6A1, CSNK2A1, KLHL20, and SCN2A in schizophrenia. The gene discussed is SCN2A; the disease is schizophrenia.