Of the 367 AGRE subjects, 17% had ApoA1 <5thCent and 22% had ApoB <5thCent, and we organized the subjects into apolipoprotein groups: combined hypolipidemia (HABL) (ApoA1 <5thCent, ApoB <5thCent): 34 (28 M, 6 F) (9% of subjects); hypoalphalipoproteinemia (HAL) (ApoA1 <5thCent, ApoB ≥5thCent): 28 (23 M, 5 F) (8%); hypobetalipoproteinemia (HBL) (ApoA1 ≥5thCent, ApoB <5thCent): 47 (35 M, 12 F) (13%); Normal (ApoA1 ≥5thCent, ApoB ≥5thCent): 258 (219 M, 39 F) (70%) (Supplementary Table 19). The gene discussed is APOB; the disease is hypobetalipoproteinemia.