This result has also been reported in other studies on multivalent COVID-19 vaccines based on the full-length S or S1 proteins of the WT virus and Beta variant.56,60 Moreover, TF-RBD-triCoV was administered as a third dose after a prime-boost with TF-RBD, and the anti-RBD IgG antibody and cross-pNAb titers were significantly elevated, especially for Beta. The gene discussed is PSMD1; the disease is COVID-19.