In fact, a recent video-oculography study has suggested that OMA complexity in ALS increases with disease severity, starting from deficits in executive eye control movements and progressing to brainstem and precerebellar/pontine circuit dysfunction,9 being consistent with the Braak staging of phosphorylated TAR DNA-binding protein 43 pathology.33 Here, TARDBP is linked to amyotrophic lateral sclerosis.