Endogenous mouse tau that accumulates within plaque-associated dystrophic processes [19], likely as a result of local disruption of MTs [11, 33, 50], is converted to insoluble NP tau aggregates that are recognized by multiple phospho-tau antibodies as well as antibodies to misfolded tau upon seeding by internalized AD-tau. The gene discussed is MAPT; the disease is Alzheimer disease.