A gene ontology analysis of biological processes (Additional file 1: Table S2) indicated multiple pathways related to macrophage/microglial function and activation that were different between the AD-tau injected 5XFAD TREM2 heterozygous and TREM KO mice (only pathways with p-value of  < 1 × 10–6 are shown). This evidence concerns the gene MAPT and Alzheimer disease.