Another hint that CME may be closely associated with AD pathology comes from genetic mutations that can lead to late onset Alzheimer’s disease (LOAD) including PICALM [174, 248], EXOC3L2 (Exocyst complex component 3-like 2; [335, 401], BIN1 [217], MEF2 (myocyte enhancer factor-2; [61], KIBRA [83], RIN3 (Ras and Rab Interactor 3; [217], and Sorla [379]. Here, SORL1 is linked to Alzheimer disease.