MAPT and Alzheimer disease: Alongside the better known pathology of Aβ plaques and neurofibrillary tangles seen in AD, actin-depolymerizing factor (ADF)/cofilin-actin rods can also occur [310] which may be precursors to Hirano bodies, actin-rich inclusions that contain tropomyosin, Tau, and cofilin, among other proteins [140, 146].