ɑ-synuclein is another pre-synaptic protein thought to have a role in the synaptic vesicle cycle including endocytosis [454], reclustering [327], and mobility [398, 461] but is found in Lewy body aggregates seen in Parkinson’s disease (for an overview on ɑ-synuclein induced synaptopathy see [45]. Here, SNCA is linked to Parkinson disease.