CXCL8 and gastric cancer: Association between tumor-associated neutrophils (TANs) and metastases is apparently caused by the release of IL-1β, IL-6, IL-8, IL-17, and TNF-α, which induce the EMT process in gastric cancer cells by activation of cell signaling pathways such as JAK2/STAT3 and ERK1/2 [53].