Of the patients who fulfilled the SLICC 2012 criteria but not the ACR 1997 criteria (30/57), the common manifestations in this cohort were fever (63%; n = 19), arthritis (40%; n = 12), nephritis (23%; n = 7) and proteinuria (20%; n = 6) while the most common immunological parameters included dsDNA (63%; n = 19), positive VDRL (47%; n = 14) and low complements (C3 and C4) (47%; n = 14) at first visit. This evidence concerns the gene C4A and nephritis.