H19 and neoplasm: In another study, for the migration and invasion of tongue squamous cell carcinoma (TSCC), long non-coding RNA H19 is highly expressed in TSCC cells, which has the ability to promote the migration and invasion of tumor cells, while H19-mediated invasion of TSCC promotes tumor metastasis in a let-7e-dependent manner through the epithelial-mesenchymal transition (EMT) pathway [24].