Expression at the protein level confirmed that up-regulated prostaglandin-endoperoxide synthase 2 (PTGS2) expression and down-regulated metallothionein-1G (MT1G), tubulin epsilon 1 (TUBE1) and autophagy-related gene 4D (ATG4D) increase the risk of pancreatic cancer and lead to a poor prognosis; however, further experimental verification is warranted [72]. The gene discussed is TUBE1; the disease is familial pancreatic carcinoma.