Related experiments further proved that Zalcitabine induces ferroptosis by inducing oxidative mtDNA damage and mitochondrial function decline, as well as TFAM degradation and activation of the cyclic GMP-AMP synthase (CGAS)- stimulator of interferon gene 1 (STING1) pathway, thereby inhibiting the growth of pancreatic cancer [51]. This evidence concerns the gene CGAS and pancreatic neoplasm.