GRN and amyotrophic lateral sclerosis: Although other analyses have remarked upon nuclear clefts as a feature of FTLD-MAPT [19], when examining the nuclei of dentate gyrus neurons, this finding also applied to other clinical entities, being abundant within three amyotrophic lateral sclerosis cases, two progranulin mutation carriers and in one non-demented control (Fig. 8b, Table 1).