CRY2 and neuroblastoma: In another case, overexpression of the proline-rich domain of tau, achieved through a cryptochrome 2-based optogenetic oligomerization module, CRY2olig [59], formed heterotypic condensates with microtubule plus-end tracking proteins (i.e., end binding 1 (EB1) protein) in SH-SY5Y neuroblastoma cells [34].