UBE2V1 and breast carcinoma: In a reverse expreriment, depletion of Uev1A in the above three cancer cell lines significantly inhibited the upregulation of CT45A, indicating that Uev1A plays a critical role in the upregulation of CT45A. Siminarly, Uev1A positively regulates the expression of CT45A downstream tumorigenic, EMT, stemness and metastatis related genes in breast cancer cells.