Based on the existed information that LncRNAs play critical roles in regulating AKI and CKD progression [15,16], and LPS-induced cell pyroptosis can be modulated by various LncRNAs, such as LncRNA CTD-2574D22.4 [18] and lncRNA UCA1 [19], we conjectured that there might exist novel LncRNAs that regulated the progression of AKI associated CKD. This evidence concerns the gene UCA1 and chronic kidney disease.