SNHG16 and hepatocellular carcinoma: There are several reports on the roles of SNHG16 gene in HCC, and the results showed that SNHG16 could promote proliferation, migration, and invasion of HCC cells [32,33], and it also might act as a ceRNA targeting miRNA to promote HCC development, such as miR-186 [34] and miR-4500 [35].