PTEN (phosphatase and tensin homolog), RECK (reversion-inducing cysteine-rich protein with Kazal motifs) and PDCD4 (programmed cell death protein 4), which are linked to decreased metastatic potential and found dysregulated in PCa, belong to the target genes of miR-21 [101,102,103,104]. This evidence concerns the gene PTEN and posterior cortical atrophy.