We have also established the EV and OIP5 stable lines in the commonly used 786-O ccRCC cells, and OIP5 overexpression did not affect all of the above oncogenic events observed in ACHN cells in vitro (data not shown), which suggests a certain level of specificity of OIP5 in promoting pRCC. This evidence concerns the gene OIP5 and nonpapillary renal cell carcinoma.