By using the TCGA RNA-sequencing data organized by UALCAN (ualcan.path.uab.edu/home, 31 March 2021) [37], OIP5 upregulation at the mRNA level in pRCC tissues was observed (Figure 1c); the upregulations reflects the level of severity and the order of unfavorable outcome of pRCC with higher expression levels in T2P over T1P tumors, CIMP tumors over other subtypes (Figure 1D), stage 3 tumors over stages 1–2 tumors, stage 4 over stage 3 tumors (Figure 1E), and N1 (lymph node metastasis) over N0 tumors (Figure 1F). The gene discussed is OIP5; the disease is metastatic malignant neoplasm in the lymph nodes.