In Hep3B cells as well as human cholangiocarcinoma HIBEpic, HuCCT1, and RBE cell lines, c-Myc supported GSH production and recycling, such that the loss of c-Myc expression in these cells led to a decrease in GSH levels and GSH/GSSG ratios [64]. This evidence concerns the gene MYC and cholangiocarcinoma.