CAP + TMZ resulted in alterations (Figure 6D) in oxidative stress response genes (HMOX1, NQO1), antioxidant-related genes (SOD1, SOD2, NRF2), endoplasmic reticulum stress response genes (HSPs like HSPA5,6,7, DDIT3), early response genes (EGR1, c-FOS, and FOSL1) an oncogene (c-MYC), tumor suppressor genes (P53 and GADD45A), and key markers of GBM, i.e., Nestin, PROM1(CD133), IDH1, and GFAP. This evidence concerns the gene GADD45A and glioblastoma.