They have demonstrable anti-angiogenic, anti-proliferative, and immunomodulatory effects as they bind to a primary protein target termed cereblon, an E3 ubiquitin ligase complex which leads to the ubiquitination and degradation of Ikaros (IKZF1) and Aiolos (IKZF3), two transcription factors that maintain MM cell function [43]. The gene discussed is IKZF1; the disease is Miyoshi myopathy.