The results showed that high S1PR1 expression in TCGA BLCA (OR: 1.922, p-value: 0.0002), GSE 32894 (OR: 1.955, p-value: 0.0757), and GSE31684 (OR: 2.94, p-value: 0.0223) was associated with worse prognosis. This evidence concerns the gene S1PR1 and bladder transitional cell carcinoma.