In addition, S1PR1 expression was positively correlated with neutrophil infiltration in three databases, where S1PR1 was associated with better prognosis, suggesting that better prognosis may due to higher neutrophil infiltration [58,59], implying that S1PR1 expression may be susceptible to the degree of immune cell infiltration in the tumor microenvironment. The gene discussed is S1PR1; the disease is neoplasm.