SAP130 and neoplasm: Seifert et al. also demonstrated that necroptosis could promote tumorigenesis by releasing chemokine (C-X-C motif) ligand 1 (CXCL1) and 130 kDa Sin3-associated polypeptide (SAP130) to induce an immunosuppressive tumor microenvironment (TME) in pancreatic ductal adenocarcinoma [19].