In the tumor stroma, the IHC expression of COL5A1, COMP, and IBSP was significantly higher in the group with BM than that in the group without BM (p = 0.001 for COL5A1, p = 0.015 for COMP, and p = 0.003 for IBSP; Figure 7). The gene discussed is IBSP; the disease is neoplasm.