If one looks at the cancers protected against by the presence of allergy/atopy or high serum IgE levels, a number of site-specific cancers stand out, these including lung cancer (in the absence of asthma) [37,38,39,45,46]; colorectal cancer, particularly rectal cancer [37,46,51,64,115]; and pancreatic cancer [37,38,50,52,64,116,117], all of which seemed to be protected against by either the presence of allergy/atopic disease or high serum IgE levels. The gene discussed is IGHE; the disease is asthma.