Karagiannis et al. [28] indicated a putative role for CD23 expressed on IL-4 stimulated monocytes in driving anti-tumour IgE antibody-dependent cell phagocytosis of ovarian tumour cells; whilst Ye et al. [89] demonstrated through cell culture models that IgE interactions with CD23 expressed on colon cancer cells could trigger cancer cell apoptosis. Here, IGHE is linked to cancer.