FOXA1 and neoplasm: Consequently, deregulation of GATA6 and HNF1B, loss of expression of the E-cadherin protein, and induction of EMT are all typical features of squamous PDAC that allow tumor cells to detach from the tumor mass and migrate [66,69]; in parallel, silencing of GATA6 also increases the metastatic capacity of PDAC cells via direct inhibition of transcription factors such as FOXA1/2 [66].