In contrast to PDAC with an activated stroma profile, tumors with a normal PDAC stroma (26%) [97] (also known as mature [83], collagen-rich [97], desmoplastic [53], and immune-rich [52] tumors) display a tumor stroma with limited cellularity [83] which is enriched in collagen deposition (mature) around tumor glands [83,97,98], similarly to what is observed in chronic pancreatitis tissues [96], but with relatively higher expression of PSCs markers (i.e., VIM and DES) together [35] or not [97] with the expression of ACTA2. This evidence concerns the gene ACTA2 and neoplasm.