Thus, histological dedifferentiation and increased capacity to dissociative growth and migration of squamous PDAC cells [36,72,84] is promoted by low expression of HNF1A/B genes [69,76] and miRNAs that regulate the EMT (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) [86], together with increased—tumor and stromal—expression of the SNAIL, ZEB1, and ZEB2 genes [86,87]. This evidence concerns the gene ZEB1 and neoplasm.