From the molecular point of view, activated stroma tumors show overexpression of numerous ECM-associated genes involved in tumor promotion (SPARC) [35,53], hypoxia (CA9), glycolysis (MCT4) [83], the Hedgehog signaling pathway [53], and poor survival (WNT2, WNT5A, MMP9, and MMP11) [35]. Here, SLC16A3 is linked to neoplasm.