Moreover, activation of specific immune evasion mechanisms in PDAC leads to an immune-exhausted PDAC phenotype (11% of all PDAC) [36] with shared features with immunogenic PDAC (i.e., immunogenic TME with lower levels of Treg cells, in association or not with deficient MMR and microsatellite instability; MSI) [10] associated with unfavorable immunosuppressive features such as upregulation of PD-L1, tumor budding, and an immune evasion phenotype, leading to a poorer biological tumor behavior similar to that of squamous PDAC [36]. This evidence concerns the gene CD274 and neoplasm.