INS and neoplasm: It consists of tumors defined by transcriptional programs typically associated with terminally differentiated pancreatic tissue, characterized by upregulation of genes involved in exocrine (NR5A2, MIST1, RBPJL) and endocrine (INS, NEUROD1, NKX2-2) tissue differentiation, β-cell development, and tumor–derived digestive enzyme and pancreatic secretion (CPA1, AMY2B, PRSS1, INS) [10,35,56].