GSK3B and neoplasm: Accordingly, squamous PDAC more frequently present with tumor and stromal [54] copy number gains and/or increased expression of genes involved in glycolysis and the pentose phosphate signaling pathway (LDHA, SLC16A3, TPI1, GAPDH, ENO1, LDHA, and PGK1), regulation of glucose homeostasis (GSK3β) and hypoxia inducer genes (HIF1A and FOXM1) [67], along with downregulation of NSDHL and other cholesterol biosynthesis genes [68].