IFNγ is a strong inducer for HLA class II molecules in UM [53]; we suggest a positive feedback loop between the tumour cells HLA class II expression, and the infiltrate: genetically bad tumours with loss of one chromosome 3 and a mutation in the BAP1 gene upregulate surface LAG3 ligands (LSECtin, Galectin-3, and HLA class II) to attract T cells which express LAG3. This evidence concerns the gene IFNG and neoplasm.