When looking at the Leiden 64-case cohort, expression of Galectin-3 (p = 0.002), one of the probes for HLA-DRalpha (p = 0.02), HLA-DQbeta2 (p = 0.02) and HLA-DPalpha (p = 0.01) was significantly higher in high-risk M3 tumours compared with low-risk D3 tumours (Figure 3). Here, LGALS3 is linked to neoplasm.