In the TCGA cohort, we observed similar correlations: M3 tumours showed a higher expression than D3 tumours for LAG3, LSECtin, Galectin-3, HLA-DRalpha, HLA-DQalpha, and HLA-DPalpha (all p = 0.001, Mann–Whitney U test) (Figure S1). Here, LGALS3 is linked to neoplasm.