As MSI is the major consequence of dMMR [37], we asked whether MSH2 and MSH6 expression regulation by NRIP1 could affect MSI in human CRC cells by analyzing five nearly monomorphic mononucleotide repeat markers (BAT-25, BAT-26, MONO-27, NR-21, NR-24) using a multiplexed PCR assay. The gene discussed is MSH2; the disease is colorectal carcinoma.