To test this hypothesis, we screened several MSI CRC cell lines by sequencing the whole NRIP1 coding exon and identified in LoVo cells a frameshift mutation that leads to the deletion of an adenosine nucleotide (c.2184delA; p.E729fs) and to a truncated protein that lacks the last 431 amino acids and exhibits a short specific RKLP sequence (Supplementary Figure S6A). This evidence concerns the gene NRIP1 and colorectal carcinoma.