FN1 and neoplasm: The tumor microenvironment (TME) in PDAC is composed of a stiff extracellular matrix (ECM) based on collagen I, elastin and fibronectin, as well as hyaluronan (HA) and other sulfated glycosaminoglycans, which create a dense network together with surrounding fibroblasts, endothelial cells and infiltrating immune cells [11].