The adhesion of MM cells to BMSCs with defective osteoblastic differentiation via the very late antigen-4 (VLA-4) (α4β1 integrin)-vascular cell adhesion molecule-1 (VCAM-1) interaction confers MM cell homing, growth, survival, and cell adhesion-mediated drug resistance [24,25]. The gene discussed is VCAM1; the disease is Miyoshi myopathy.