Among these miRNAs, miRNAs such as miR-21-5p increase the RANKL/OPG ratio in bone marrow stromal cells in patients with MM [74], while others, including miR-342-3p, miR-363-5p, and miR-203a-3p, suppress osteoblastogenesis through targeting the RUNX2, BMP/SMAD, and canonical WNT/β-catenin pathways [75,76]. Here, RUNX2 is linked to Miyoshi myopathy.