In addition, osteoblastic differentiation is suppressed by factors overproduced from MM cells and/or their surrounding microenvironment in bone, including Wnt inhibitors (DKK1, sclerostin, and sFRP2,3), TNFα, IL-7, IL-3, TGF-β, and activin A [15,16,17]. This evidence concerns the gene IL3 and Miyoshi myopathy.