For example, studies have confirmed that the nucleus of Fusobacterium nucleatum (F. nucleatum), reported to promote CRC [97]) activates TLR4-MyD88 innate immune signaling and causes the down-regulation of miR-18a* and miR-4802, which in turn increases their target genes Unc-51 Like Autophagy Activating Kinase 1 (ULK1) and Autophagy Related 7 (ATG7), two key components of the autophagy pathway, thereby regulating CRC chemoresistance [98]. This evidence concerns the gene TLR4 and colorectal carcinoma.