Along similar lines, using a highly aggressive PKT GEMM mouse of PDAC that phenocopies human disease in terms of dense stroma and presence of immunosuppressive milieu [57], previously we have demonstrated that combined inhibition of PI3K/Akt/mTOR using Urolithin A effectively reprograms the fibroinflammatory tumor stroma to promote an anti-tumor immune microenvironment by decreasing immunosuppressive TAMs and augmenting T-cell recruitment within the TME of PDAC (Figure 2) [15]. The gene discussed is PIK3CA; the disease is neoplasm.