SMYD3 and esophageal squamous cell carcinoma: Furthermore, in HCC and esophageal squamous cell carcinoma, SMYD3 overexpression was associated with the expression of retinoblastoma protein-interacting zinc finger 1 (RIZ1) [22,41], which has a role in the G2/M checkpoint and is downregulated in several types of human cancers [53].