Altogether, in vivo studies and the above-described sophisticated work carried out by Thomenius et al. in cellular models [28] suggest that investigating the role of SMYD3 in tumorigenesis and cancer progression requires representative and reliable model systems allowing to preserve cellular heterogeneity and obtain biochemical and morphological characteristics that are similar to in vivo cancer tissue, as they influence gene expression and cell behavior [44]. The gene discussed is SMYD3; the disease is cancer.