In a previous paper by our group, the expression and activity of SMYD3 were evaluated in a preclinical model of CRC, i.e., APCMin/+ mice treated with the carcinogen azoxymethane (AOM), and found to be strongly upregulated throughout tumorigenesis at both the mRNA and the protein levels, along with its downstream targets [9]. This evidence concerns the gene SMYD3 and colorectal carcinoma.