SMYD3 and pachyonychia congenita: Indeed, SMYD3 has been found overexpressed in several types of cancers, including colorectal (CRC), breast (BC), gastric (GC), pancreatic (PC), ovarian (OvCa), prostate and lung cancer, and hepatocellular carcinoma (HCC) [1], with high SMYD3 levels being associated with reduced overall survival and worse prognosis [11,20,21,22,23,24,25].