Indeed, SMYD3 was found overexpressed in liver tumors in mice treated with diethylnitrosamine (DEN) as a model for HCC, and in colon tumors in mice treated with dimethylhydrazine/dextran sodium sulfate (DMH/DSS) and APCMin/+ mice treated with the carcinogen AOM as a model for CRC [9,11]. This evidence concerns the gene SMYD3 and hepatocellular carcinoma.