However, CHEK2 PV accounted for 13.1% of all germline PV (identified in 8 of 298 PDAC patients (2.7%)), a proportion comparable to ATM. CHEK2 was initially reported as a multi-organ cancer susceptibility gene associated with breast, prostate, colon, and pancreas cancer, with low-to-moderate penetrance [25]. This evidence concerns the gene CHEK2 and cancer.