ATM and acquired polycythemia vera: Only five (3.4%) of them harbored a PV in an established PDAC-predisposition gene, including 2 × BRCA2, 2 × PALB2, and 1 × ATM. Interestingly, the age at PDAC onset in these PV heterozygotes ranged between 59 and 71 years, while no PV in an established PDAC-predisposition gene was identified in the 52 patients diagnosed before the age of 59 years (Figure 2C).