Indeed, mutant K-ras and p53 activated ARF6 (ADP Ribosylation Factor 6)-ASAP1 (ArfGAP with SH3 domain, ankyrin repeat, and PH domain 1) axis through PDGFR (platelet-derived growth factor receptor) signaling to control PD-L1 expression in pancreatic cancer cells [182]. Here, ARF6 is linked to familial pancreatic carcinoma.