Furthermore, consistent with a reduction in DNMT1 expression, we observed an upregulation of STAT5A, RAB13, GATA3, TGFB1 and IL-2RG (Figure 5A,D), which are all DNMT1 target genes, epigenetically silenced in ALK+ ALCL [17,18,20,29]. The gene discussed is DNMT1; the disease is anaplastic large cell lymphoma.