Epigenetic modulation is another mechanism involved in the pathogenesis of LGLL, as suggested by the disruption of the negative feedback of SOCS3 during IL-6 mediated immune responses, the restoration of its expression in LGLL cells treated with 5-aza-2′-deoxycytidine (a hypomethylating agent), and the absence of mutations in this gene [61]. Here, IL6 is linked to T-cell large granular lymphocyte leukemia.