An increased expression of both PDGF receptor type b and PDGF-bb results in an autocrine loop and activation of several pathways involved in LGLL (e.g., JAK-STAT, Ras-RAF-MEK1-ERK, and PI3K-Akt) [23,27]. The gene discussed is AKT1; the disease is T-cell large granular lymphocyte leukemia.