For example, BC tumour grading is a widely used prognosticator and has only moderate concordance between pathologists (Kappa = 0.48) [32], whereas excellent agreement (ICC 0.87, 95% CI 0.799–0.93) has been achieved for Ki67, albeit with considerable effort, but its use in BC is limited [31]. The gene discussed is MKI67; the disease is neoplasm.