However, CRP failed to reach the top markers in two of the five studies that included it [23,36]; did not detect advanced adenoma in Tao et al., with an AUC of 0.5 [37]; and performed only modestly as an early detection biomarker in the remaining two studies, with an AUC of 0.64 for advanced adenoma in Lim et al. [30], and a combined AUC (CRP+SAA) of 0.62 for colorectal cancer in Toriola et al. [35]. Here, CRP is linked to adenoma.